A different sequencing method that chemically cleaved DNA at specific bases, developed by Allan Maxam and Walter Gilbert, was the dominant technology into the 1980s. Radiolabeled DNA samples were incubated in four separate reactions, each of which contained a chemical that cleaved after a different nucleotide — either A/G, G, C, or C/T. By adding the right amount of each chemical, it was possible to produce different fragments chopped off at each individual base. The sequence could then be read using gel electrophoresis and autoradiography. Maxam–Gilbert sequencing was easier than the plus and minus method to run and interpret, but was eventually surpassed by Sanger’s chain termination method, which molecular biologists found both technically preferable and more “elegant” since it mirrored the natural copying of DNA.
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In an interview with Fortune Editor in Chief Alyson Shontell on the Titans and Disruptors of Industry podcast, Khosla said AI will be capable of performing 80% of all jobs—from physicians to radiologists, accountants to salespeople. This massive AI displacement would essentially narrow labor costs to zero, also making goods and services much less expensive. Ultimately, Khosla said, today’s youngest generation would not need to acquire a college degree to find a job—or even need to find a job at all.
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